位置:首页 > 品牌 > Sigma-Aldrich >

ALK2 (R206H), Active

品牌
Sigma-Aldrich
货号
SRP0719
规格纯度
PRECISIO® Kinase, recombinant
参考价格
5467.45 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

Useful for kinase assay.

生化/生理作用

Recombinant human ALK2 (R206H) (147-end) was expressed by Baculovirus in Sf9 insect cells using an N-terminal GST tag. ALK2 belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins which encodes activin A type I receptor. ALK2 signals a particular transcriptional response in concert with activin type II receptors. Mutations in ALK2 are associated with fibrodysplasia ossificans progressiva (FOP) and the mutations are located in or adjacent to the GS regulatory region or active site of the kinase. The mutations in ALK2 were predicted by protein structure homology modeling to activate the ALK2 protein and enhance receptor signaling (1). Dysregulated ALK2 kinase activity plays a role in the pathogenesis of FOP (2).

重悬

Formulated in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, with 25% glycerol.

储存及稳定性

Store in aliquots at -70℃. Avoid freeze/thaw cycles.

法律信息

PRECISIO is a registered trademark of sigma-aldrich Co. LLC

产品性质

重组expressed in baculovirus infected Sf9 cells
测定70-95% (SDS-PAGE)
形式frozen liquid
specific activity5-7 nmol/min·mg (radiometric)
分子量 ~67 kDa
浓度0.1 μg/μL
登记号NM_001105
运输dry ice
储存温度−70℃
Gene Informationhuman ... ALK2(90)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品
| 首页 | 联系我们 | 会员服务 | 广告服务 | 友情链接 |
版权所有 CopyRight © 2008-2024 粤ICP备08119708号