位置:首页 > 品牌 > Sigma-Aldrich >

Akt1 active human

品牌
Sigma-Aldrich
货号
SRP0353
规格纯度
recombinant, expressed in baculovirus infected Sf9 cells, ≥75% (SDS-PAGE)
参考价格
7031.79 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

AKT1 (v-akt murine thymoma viral oncogene homolog 1) is a Ser/Thr protein kinase, and is also called protein kinase B (PKB). This protein is activated when it is phosphorylated at serine 473 and threonine 308. This gene is localized to human chromosome 14q32.32.

应用

Akt1 active human has been used for the testing of recombinant mouse p21 proteins as its substrates using in vitro protein kinase assay.

生化/生理作用

AKT1 (v-akt murine thymoma viral oncogene homolog 1) is responsible for the phosphorylation and cytoplasmic localization of CKDN1A (cyclin-dependent kinase (CDK) inhibitor 1, also referred to as p21). However, p21 is one of the CDKNs which normally resides in the nucleus and its cytoplasmic localization, mediated by AKT1, is common to various cancers where it suppresses proteins essential for apoptosis. Studies show that up-regulation of AKT1 serves as a poor prognostic marker in breast cancer, which however, depends upon factors including population, hormone receptor status, and hormonal or trastuzumab therapy status.

基本信息

NACRESNA.32

产品性质

生物来源human
重组expressed in baculovirus infected Sf9 cells
测定≥75% (SDS-PAGE)
形式aqueous solution
分子量 60.2 kDa
包装pkg of 10 μg
NCBI登记号NM_001014432
UniProt登记号P31749
运输dry ice
储存温度−70℃
Gene Informationhuman ... AKT1(207)

安全信息

象形图GHS07GHS08
警示用语:Danger
危险声明H315 - H319 - H360D
预防措施声明P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
危险分类Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
储存分类代码6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品
| 首页 | 联系我们 | 会员服务 | 广告服务 | 友情链接 |
版权所有 CopyRight © 2008-2024 粤ICP备08119708号