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Acenocoumarol

醋硝香豆素

品牌
Sigma-Aldrich
CAS
152-72-7
货号
SML0074
规格纯度
≥98% (HPLC)
参考价格
1202.81 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

Acenocoumarol was used to study the role of P-glycoprotein in transport of oral vitamin K in Caco-2 cells and as an LC/MS standard.
Acenocoumarol has been used as a standard for the determination of coumarins in cosmetics.

包装

10, 50 mg in glass bottle

生化/生理作用

Acenocoumarol is effective against thromboembolic disorders.
Acenocoumarol is a warfarin analog, an anticoagulant that inhibits Vitamin K epoxide reductase. This results in depletion of the reduced form of vitamin K (vitamin KH2), limiting the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S, resulting in decreased prothrombin levels and the amount of thrombin generated.

特点和优势

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

基本信息

经验(实验)分子式C19H15NO6
分子量353.33
EC 号205-807-3
MDL编号MFCD00137816
PubChem化学物质编号329825137
NACRESNA.77

产品性质

测定≥98% (HPLC)
形式powder
颜色 white to tan
溶解性DMSO, heptane and xylene: ≥17 mg/mL
创始人Novartis
储存温度−20℃
SMILES stringCC(=O)CC(c1ccc(cc1)[N+]([O-])=O)C2=C(O)c3ccccc3OC2=O
InChI1S/C19H15NO6/c1-11(21)10-15(12-6-8-13(9-7-12)20(24)25)17-18(22)14-4-2-3-5-16(14)26-19(17)23/h2-9,15,22H,10H2,1H3
InChI keyVABCILAOYCMVPS-UHFFFAOYSA-N
Gene Informationhuman ... VKORC1(79001)

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 - H315 - H319 - H335
预防措施声明P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
危险分类Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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