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α-L-Fucosidase Assay Kit

品牌
Sigma-Aldrich
货号
MAK444
规格纯度
Sufficient for 100 colorimetric tests
参考价格
5184.11 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

α-L-Fucosidase (AFU) is an enzyme coded by the FUCA1 gene in humans and catalyzes the breakdown of L-Fucose. A genetic deficiency in this enzyme results in a neurovisceral storage disease, fucosidosis, which is characterized by the accumulation of fucose. Low serum activity of fucosidase has also been linked to ovarian caricinoma. Elevated fucosidase serum activity has been observed in patients with diabetes, hyperthyroidism, cirrhosis, and hepatitis. Increased activity has been associated with lung, breast, stomach, ovary, uterus, and liver carcinomas.

特点和优势

  • High sensitivity and wide linear range. Linear detection range (10 μL sample): 1 to 100 U/L.
  • Simple add-mix-read procedure allows reliable quantitation of fucosidase activity within 20 minutes.
  • Compatible with high-throughput handling systems.

适用性

The kit is suitable for the quantitative determination of α-L-Fucosidase activity in plasma, serum, tissue, cell lysate, etc.

原理

The non-radioactive, colorimetric α-L-Fucosidase Assay Kit is based on the cleavage of 4-nitrophenol from the synthetic substrate. Nitrophenol becomes intensely colored after addition of the stop reagent. The increase in absorbance at A405 nm after addition of the stop reagent is directly proportional to the enzyme activity.

产品性质

质量水平100
detection methodcolorimetric
相关疾病cancer, diabetes; endocrinological disorders, hepatitis; gastrointestinal diseases
储存温度2-8℃

安全信息

象形图GHS07
警示用语:Warning
危险声明H319
预防措施声明P264 - P280 - P305 + P351 + P338 - P337 + P313
危险分类Eye Irrit. 2
储存分类代码10 - Combustible liquids
WGKWGK 2

Sigma-Aldrich

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