产品说明
一般描述
Vancomycin is a glycopeptide antibiotic, which was initially isolated from Streptomyces orientalis. It is effective against multidrug-resistant MRSA strain (methicillin-resistant Staphylococcus aureus). However, it is nephrotoxic as it is mainly excreted by the kidneys. It has a core heptapeptide having aliphatic amino acids at positions 1 and 3. It is mainly effective against gram-positive bacteria.
应用
Vancomycin hydrochloride may be used-
- for the assessment of the antimicrobial activity of vancomycin hydrochloride against Mycobacterium tuberculosis in nonreplicating persistence (NRP) using low-oxygen-recovery assay (LORA) and against a luciferase reporter strain of M. tuberculosis in a fermentor-grown culture adapted to low oxygen conditions
- for the estimation of biomass in a culture of various strains of bacteria
- as a positive control for E. coli and Staphylococcus aureus in antibacterial activity assay.
生化/生理作用
Vancomycin is bactericidal in nature, where it inhibits the synthesis of peptidoglycan. It forms hydrogen bond with the peptidoglycan precursor UDP-N-acetylmuramylpentapeptide, and forms a stoichiometric 1:1 complex. Thus, it prevents the growth of the glycan polymer of peptidoglycan by transglycosylase enzyme. It is a frequently used antibiotic for the treatment of peritonitis caused by gram-positive bacteria in patients with continuous ambulatory peritoneal dialysis. In patients with cirrhosis, it is used to control portal systemic encephalopathy. Mice with Clostridium difficile infection (CDI) had better clinical outcome when treated with vancomycin as opposed to the outcome on treatment with metronidazole.
包装
10ML
其他说明
Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible liquids
基本信息
| 经验(实验)分子式 | C66H75Cl2N9O24 · xHCl |
| 分子量 | 1449.25 (free base basis) |
| NACRES | NA.85 |
产品性质
| 质量水平 | 200 |
| 生物来源 | Streptomyces orientalis |
| 形式 | liquid |
| 储存条件 | (Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510) Combustible liquids.) |
| 浓度 | 100 mg/mL in DMSO |
| 颜色 | colorless to faint tan |
| 作用机制 | cell wall synthesis | interferes |
| 抗生素抗菌谱 | Gram-positive bacteria |
| 储存温度 | −20℃ |
安全信息
| 象形图 |  |
| 警示用语： | Danger |
| 危险声明 | H317 - H334 |
| 预防措施声明 | P261 - P272 - P280 - P284 - P302 + P352 - P304 + P340 + P312 |
| 危险分类 | Resp. Sens. 1 - Skin Sens. 1 |
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 2 |
| 闪点(F) | 188.6 °F - closed cup |
| 闪点(C) | 87 ℃ - closed cup |
