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TPO from mouse

品牌
Sigma-Aldrich
货号
SRP3236
规格纯度
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
参考价格
4312.08 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

TPO (thrombopoietin) is a hematopoietic cytokine expressed in multiple tissue types. It is predominantly produced by liver and kidney and acts as a ligand for the cell surface receptor c-mpl.
TPO is a lineage specific growth factor, produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and murine TPO exhibits cross-species reactivity. Recombinant murine TPO is a fully biologically active 174 amino acid polypeptide (18.7 kDa), which contains the erythropoietin-like domain of the full length TPO protein.

生化/生理作用

TPO (thrombopoietin) is the key regulator of thrombopoiesis for platelet lineage. In both mice and humans, inactivation of this gene results in significant decrease in number of mature platelets produced by marrow progenitors. Transgenic mice with increased expression of this protein show progressive fibrosis and osteosclerosis of the bone marrow, as well as histological changes in kidneys, leading to mesangioproliferative glomerulopathy.

序列

SPVAPACDPR LLNKLLRDSH LLHSRLSQCP DVDPLSIPVL LPAVDFSLGE WKTQTEQSKA QDILGAVSLL LEGVMAARGQ LEPSCLSSLL GQLSGQVRLL LGALQGLLGT QLPLQGRTTA HKDPNALFLS LQQLLRGKVR FLLLVEGPTL CVRRTLPTTA VPSSTSQLLT LNKF

外形

Lyophilized from 10 mM Sodium Phosphate, pH 8.0.

重悬

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of ?0.5 mg/ml. Slow to dissolve. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃.

基本信息

NACRESNA.32

产品性质

生物来源mouse
重组expressed in E. coli
测定≥98% (HPLC)
≥98% (SDS-PAGE)
形式lyophilized
效能<1.0 ng/mL ED50
分子量 18.7 kDa
包装pkg of 10 μg
technique(s)cell culture | mammalian: suitable
杂质<0.1 EU/μg endotoxin, tested
颜色 white
UniProt登记号P40226
运输wet ice
储存温度−20℃
Gene Informationmouse ... THPO(21832)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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