产品说明
一般描述
CD95, also known as Fas (fatty acid synthase) cell surface death receptor/APO-1, is encoded by the gene mapped to human chromosome 10q23.31. The encoded protein belongs to the tumor necrosis factor receptor superfamily and is expressed on a variety of cells including activated T and B cells. CD95 contains a death domain.
The antibody LT95 reacts with CD95 (Fas/APO-1), a 46 kDa single chain type I glycoprotein of the tumour necrosis factor/nerve growth factor (TNF/NGF) receptor superfamily, expressed on a variety of normal and neoplastic cells. It seems that the antibody LT95 does not induce Fas mediated apoptosis, although it cross-blocks anti-Fas DX2 antibody that recognizes a functional epitope of Fas molecule.
免疫原
HUT-78 human T cell lymphoma cell line
应用
Monoclonal Anti-CD95 antibody produced in mouse has been used as a apoptosis inducer.
生化/生理作用
CD95/ Fas (fatty acid synthase) cell surface death receptor interacts with its natural ligand (FasL/CD95 L) and plays a vital role in regulation of T-cell homeostasis, by promoting apoptosis via activation-induced cell death (AICD). Mutation in the gene has been associated with the development of Sézary syndrome (SS) and Canale–Smith syndrome. CD95 gene loss can be used as a genetic marker of PSA recurrence after radical prostatectomy.
特点和优势
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外形
Solution in Tris buffered saline, pH 8.0, with 15 mM sodium azide.
基本信息
NACRES | NA.41 |
产品性质
生物来源 | mouse |
偶联物 | unconjugated |
抗体形式 | purified immunoglobulin |
antibody product type | primary antibodies |
克隆 | LT95, monoclonal |
形式 | buffered aqueous solution |
species reactivity | human |
浓度 | 1 mg/mL |
technique(s) | flow cytometry: suitable |
同位素/亚型 | IgG1 |
NCBI登记号 | NM_000043.3 |
UniProt登记号 | P25445 |
运输 | wet ice |
储存温度 | 2-8℃ |
Gene Information | human ... FAS(355) |
安全信息
储存分类代码 | 12 - Non Combustible Liquids |
WGK | WGK 1 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |