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Monoclonal Anti-CD20 antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB4700121
规格纯度
clone MEM-97, purified immunoglobulin, buffered aqueous solution
参考价格
3548.32 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Cluster of differentiation 20 (CD20), also referred to as membrane spanning 4-domains A1 (MS4A1), is expressed on the surface of human B lymphocytes and on a small subset of T cells. The 33-35kDa, non-glycosylated protein has four membrane-spanning domains with both the amino and carboxy termini of the protein localized to the cytoplasm and a short 43 residue-extracellular segment. It is part of the membrane-spanning 4A gene family. The gene encoding MS4A1 is localized on human chromosome 11q12-13.

免疫原

Raji human Burkitt′s lymphoma cell line

应用

The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 10 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

生化/生理作用

Cluster of differentiation 20 (CD20) participates in the development and cell cycle progression in B-cells. It has been found to interact with proteins like adapter protein p75/80, CD40 and major histocompatibility complex class II proteins (MHC II). It may participate in Ca2+ influx across plasma membranes, maintenance of Ca2+ concentration and activation of B-cells. CD20 activates Src leading to rapid phosphorylation of phospholipase C-γ1 (PLC-γ1) and PLC-γ2, in turn activating caspase-3 signaling of apoptosis. Overexpression of the gene has been associated with the development of primary cutaneous T-cell lymphomas (CTCL).

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源mouse
偶联物unconjugated
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆MEM-97, monoclonal
形式buffered aqueous solution
species reactivitypig, bovine, human
浓度1 mg/mL
technique(s)flow cytometry: suitable
同位素/亚型IgG1
NCBI登记号NM_021950.3
UniProt登记号P11836
运输wet ice
储存温度2-8℃
Gene Informationhuman ... MS4A1(931)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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