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MANF human

品牌
Sigma-Aldrich
货号
SRP3290
规格纯度
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
参考价格
4578.32 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

MANF has been shown to promote survival, growth and function of dopamine specific neurons. MANF and its structural homolog CDNF, each contain an N-terminal saposin-like lipid binding domain, and a carboxyl-terminal domain, which is not homologous to previously characterized protein structures. MANF and CDNF can prevent 6-OHDA induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson disease.

生化/生理作用

MANF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. Recombinant human MANF is an 18.1 kDa protein consisting of 158 amino acids including 8 cysteine residues.

外形

Lyophilized from 10 mM Sodium Phosphate, pH 7.0.

重悬

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃.

基本信息

NACRESNA.32

产品性质

生物来源human
重组expressed in E. coli
测定≥98% (HPLC)
≥98% (SDS-PAGE)
形式lyophilized
效能15-25 μg/mL ED50
分子量 18.1 kDa
包装pkg of 25 μg
杂质<0.1 EU/μg endotoxin, tested
颜色 white to off-white
UniProt登记号P55145
运输wet ice
储存温度−20℃
Gene Informationhuman ... MANF(7873)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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