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Anti-PU.1 antibody, Rabbit monoclonal

品牌
Sigma-Aldrich
货号
SAB5500170
规格纯度
recombinant, expressed in proprietary host, clone SP238, affinity isolated antibody
参考价格
4731.57 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

PU.1 is a transcription factor of the Ets family and activates target genes through the purine-rich PU-box. PU.1 plays an important role for the differentiation of myeloid cells and early B cell lymphocytes. PU.1 is overexpressed in some B cell lymphoma, Hodgkin, and non- Hodgkin lymphoma.
Spi-1 proto-oncogene (SPI1), also known as PU.1, is a mammalian transcription factor. It is encoded by the gene mapped to human chromosome 11p11.2. The encoded protein belongs to the E26 transformation specific (Ets) family of transcription factors. SPI1 is characterized with a C-terminal domain, an N-terminal transactivation domain and a central PEST domain involved in protein-protein interaction. The protein is mainly expressed in cells of the hematopoietic lineage such as macrophages, granulocytes and B lymphocytes.

免疫原

Synthetic peptide derived from the internal region of the human PU.1 protein.

生化/生理作用

Spi-1 proto-oncogene (SPI1)/ PU.1 plays an essential role in myeloid development. It also acts as a transcription activator and is involved in macrophage proliferation. In addition, PU.1 along with other transcription factors, plays a vital role in fetal hematopoiesis. PU.1 controls cellular communication in the immune system. Thus, loss/reduced gene expression leads to loss of cellular communication, which in turn is associated with the development of leukemia.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平100
重组expressed in proprietary host
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆SP238, monoclonal
species reactivityhuman (tested)
species reactivity (predicted by homology)rat, mouse, pig
technique(s)immunohistochemistry: 1:100
同位素/亚型IgG
UniProt登记号P17947
运输wet ice
储存温度2-8℃
Gene Informationhuman ... SPI1(6688)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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