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Anti-phospho-MEK1/2 (pSer221) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4504467
规格纯度
affinity isolated antibody
参考价格
5045.46 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

免疫原

The antiserum was produced against synthesized peptide derived from human MEK1/2 around the phosphorylation site of Ser221.

Immunogen Range: 193-242

生化/生理作用

MAP2k1/2 (dual specificity mitogen-activated protein kinase kinase 1/2) is a serine threonine kinase and is required for ERK (extracellular-signal-regulated kinase) activation. Activation of ERK is associated with production of IL-10 (interleukin 10) and IL-12. Absence of the Map2k1 gene results in embryonic lethality. Map2k1 is responsible for the stimulation of epidermal proliferation, regulating cell migration in fibroblasts. Deficiency of Map2k1 protein causes lupus-like syndrome. The gene encoding Map2k1 is localized on human chromosome 15q22.31 and the MAP2K2 gene is localized on human chromosome 19p13.3.

特点和优势

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外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen 43 kDa
species reactivityhuman, rat, mouse
浓度~1 mg/mL
technique(s)ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号P36507
Q02750
UniProt登记号P36507
运输wet ice
储存温度−20℃
Gene Informationhuman ... MAP2K1(5604), MAP2K2(5605)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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