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Anti-phospho-Lck (pTyr505) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4300275
规格纯度
affinity isolated antibody
参考价格
5001.78 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

免疫原

Peptide sequence around phosphorylation site of tyrosine 505 (G-Q-Y(p)-Q-P), according to the protein LCK.

特点和优势

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目标描述

Tyrosine kinase that plays an essential role for the selection and maturation of developing T-cell in the thymus and in mature T-cell function. Is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors and plays a key role in T-cell antigen receptor(TCR)-linked signal transduction pathways. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, and thereby recruits the associated LCK to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosines-based activation motifs (ITAMs) in the cytoplasmic tails of the TCRgamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. In addition, contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, and upon engagement of the CD2 molecule, LCK undergoes hyperphosphorylation and activation. Also plays a role in the IL2 receptor-linked signaling pathway that controls T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR.

外形

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

基本信息

MDL编号MFCD06798495
NACRESNA.41

产品性质

生物来源rabbit
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量 ~56 kDa
species reactivityhuman
浓度1 mg/mL
technique(s)western blot: 1:500-1:1000
同位素/亚型IgG
免疫原序列(G-Q-YP-Q-P)
NCBI登记号NP_001036236.1
UniProt登记号P06239
运输wet ice
储存温度−20℃
Gene Informationhuman ... LCK(3932)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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