产品说明
一般描述
Insulin receptor (INSR) is located on human chromosome 19. It has 22 exons spanning 120 kilobases. The gene product of INSR has a leader sequence of 27 amino acids.
免疫原
The antiserum was produced against synthesized peptide derived from human IR around the phosphorylation site of Tyr1355.
Immunogen Range: 1326-1375
生化/生理作用
Insulin binds to its receptor (INSR) or to the structurally related insulin-like growth factor-I receptor (IGFIR) to control the development and apoptosis of cells. Aberrations in exon 17 of insulin receptor (INSR) gene result in PCOS (polycystic ovary syndrome). It plays a key role in insulin metabolism. Mutations in INSR results in insulin-resistant syndromes like leprechaunism (donohue syndrome), rabson–mendenhall syndrome and type A insulin resistance.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
产品性质
| 生物来源 | rabbit |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen 156 kDa |
| species reactivity | human, mouse, rat |
| 浓度 | ~1 mg/mL |
| technique(s) | ELISA: 1:10000 immunohistochemistry: 1:50-1:100 western blot: 1:500-1:1000 |
| NCBI登记号 | P06213 |
| UniProt登记号 | P06213 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... INSR(3643) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
