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Anti-ESR1 (Ab-106) antibody produced in rabbit

抗-ESR1 (Ab-106) 兔抗

品牌
Sigma-Aldrich
货号
SAB4300345
规格纯度
affinity isolated antibody
参考价格
5045.46 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Estrogen receptor 1 (ESR1) encodes estrogen receptor α (ERα) protein, otherwise known as nuclear receptor subfamily 3, group A, member 1 (NR3A1), binds to estrogen. High expression of ERα is observed in tissues such as the epididymis, uterus, kidney and adrenal glands. In human chromosome, the gene ESR1 is localized on 6q25.1-q25.2.

免疫原

Peptide sequence around aa. 104-108 (S-P- S-P-L), according to the protein ESR1.

生化/生理作用

Estrogen receptor 1 (ESR1) interacts with the nuclear transcription factor Sp1 in the presence of estradiol and regulates expression of diverse cellular and viral genes. ESR1 upon activation by estradiol interacts with transcription factor Sp3 and down regulates vascular endothelial growth factor (VEGF) in endometrial cancer cells. ESR1 tethers to DNA by protein-protein interaction with other transcription factor like activator protein 1 (AP1) family members like c-Jun, c-Fos and activating transcription factor (ATF). ESR1 and NF-κB cooperatively upregulates anti-apoptotic Baculoviral IAP (inhibitor of apoptosis protein) Repeat Containing 3 (BIRC3) and promotes breast cancer cell survival and tumor progression. Deleted in bladder cancer protein 1 (DBC1) modulates the expression of ESR1 and may promote the proliferation of breast cancer tissues. Interleukin-6 expression is suppressed by ligand activated ESR1 through interaction with NF-κB and thereby inhibits osteoporosis. ESR1 is potent in maintaining human immunodeficiency virus (HIV) latency and it is noted that latency maintenance and the amount of HIV RNA is gender specific, since women are more sensitive to estrogen.

特点和优势

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目标描述

Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

外形

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量 ~66 kDa
species reactivityrat, mouse, human
浓度1 mg/mL
technique(s)immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
western blot: 1:500-1:1000
同位素/亚型IgG
免疫原序列(S-P-S-P-L)
NCBI登记号NP_000116.2
UniProt登记号P03372
运输wet ice
储存温度−20℃
Gene Informationhuman ... ESR1(2099)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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