产品说明
一般描述
CSF1R (colony stimulating factor 1 receptor) or FMS, acts as a receptor for CSF1, and regulates monocyte and macrophage functioning. It is a member of the platelet-derived growth factor (PDGF) family of proteins, and is a type III RTK (receptor tyrosine kinase). CSF1R is composed of five immunoglobulin (Ig)-like domains, a transmembrane region, a juxtamembrane domain and kinase insert domain (KID) intersecting the kinase domain.
免疫原
Peptide with sequence KNIHLEKKYVR, from the internal region of the protein sequence according to NP_005202.2
生化/生理作用
CSF1R (colony stimulating factor 1 receptor), and its ligand CSF1 are linked to poor prognosis in patients with solid tumors, and in patients with female reproductive cancers. In breast cancers, with decreased claudin levels, this protein regulates the switch between proliferative and invasive state of the tumor, acting downstream of TGFβ (tumor growth factor β). Haploinsufficiency in this receptor might lead to aberration of microglial function, which might be a contributor to the pathogenesis of hereditary diffuse leukoencephalopathy with spheroids (HDLS).
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | goat |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| species reactivity | mouse, canine, rat, human |
| technique(s) | indirect ELISA: suitable western blot: suitable |
| UniProt登记号 | P07333 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... CSF1R(1436) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
