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ANGPTL-3 human

品牌
Sigma-Aldrich
货号
SRP3317
规格纯度
recombinant, expressed in CHO cells, ≥98% (SDS-PAGE), ≥98% (HPLC)
参考价格
4374.74 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

ANGPTL-3 (Angiopoietin like protein 3) is a member of the angiopoietin family of structurally related proteins, characterized by a coiled N-terminal domain and a C-terminal fibrinogen like domain. It is mainly present in the hepatocytes and is also secreted into circulation. The gene is mapped to human chromosome 1p31.
Recombinant human ANGPTL-3 is a glycoprotein that migrates by SDS-PAGE (sodium dodecyl sulfate polyacrylamide gel electrophoresis) analysis at an apparent molecular weight of 62kDa, and contains 452 amino acid residues including a C-terminal His tag.

生化/生理作用

ANGPTL-3 (Angiopoietin like protein 3) can exert activities related to both angiogenesis and lipid metabolism. ANGPTL-3 inhibits lipoprotein lipase (LPL) and endothelial lipase (EL), which has the effect of increasing plasma levels of triglycerides and HDL (high-density lipoprotein)-associated cholesterol. The fibrinogen like portion of the ANGPTL-3 protein can bind α-5/β-3 integrins leading to endothelial cell adhesion and migration. Mutations in this gene can result in familial combined hypobetalipoproteinemia.

外形

Lyophilized from 10mM Sodium Phosphate, pH 7.5.

重悬

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃.

基本信息

NACRESNA.32

产品性质

生物来源human
重组expressed in CHO cells
测定≥98% (HPLC)
≥98% (SDS-PAGE)
形式lyophilized
分子量 62.0 kDa
包装pkg of 50 μg
杂质 endotoxin, tested
颜色 white to off-white
UniProt登记号Q9Y5C1
运输wet ice
储存温度−20℃
Gene Informationhuman ... ANGPTL3(27329)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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