产品说明
一般描述
CREB is a beta ZIP transcription factor that activates target genes through cAMP response elements. CREB is able to mediate signals from numerous physiological stimuli, resulting in regulation of a broad array of cellular responses. While CREB is expressed in numerous tissues, it plays a large regulatory role in the nervous system. CREB is believed to play a key role in promoting neuronal survival, precursor proliferation, neurite outgrowth and neuronal differentiation in certain neuronal populations. CREB promotes outgrowth and differentiation as a mediator of Neurotrophin pathways. CREB is able to selectively activate numerous downstream genes through interactions with different dimerization partners. CREB is activated by phosphorylation at Ser133 by various signaling pathways including Erk, Ca2+ and stress signaling.
特异性
Reacts with CREB.
免疫原
Recombinant CREB-A protein.
应用
Research Sub Category
Transcription Factors
Western blot: 1-5 μg/mL. Recognizes the ~43kDa protein.
ELISA: 0.1-1.0 μg/mL
Optimal working dilutions must be determined by end user.
Research Category
Epigenetics & Nuclear Function
Anti-CREB Antibody is a Mouse Monoclonal Antibody for detection of CREB also known as cAMP-response Element Binding Protein & has been validated in ELISA & WB.
联系
Replaces: 04-218
外形
Format: Purified
Purified immunoglobulin. Liquid in PBS containing 0.1% sodium azide.
储存及稳定性
Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.
分析说明
Control
Jurkat nuclear extract, A-431 whole cell lysate
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
法律信息
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
产品性质
| 质量水平 | 100 |
| 生物来源 | mouse |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | monoclonal |
| species reactivity | mouse, rat, human |
| manufacturer/tradename | Chemicon® |
| technique(s) | ELISA: suitable western blot: suitable |
| 同位素/亚型 | IgG1 |
| NCBI登记号 | NM_004379.2 NM_134442.2 |
| UniProt登记号 | P16220 |
| 运输 | wet ice |
| Gene Information | human ... CREB1(1385) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
