产品说明
应用
Zotepine has been used as an anti-psychotic agent:
- in biophysical studies with serotonin 2A receptor (5-HT2AR)
- to study its effects on the inhibition of human organic cation transporter 1 (hOCT1)
- to study its protective effects on the human embryonic kidney (HEK cells)
包装
10, 50 mg in glass bottle
生化/生理作用
Zotepine acts as an antagonist of dopamine D1, D2, and serotonin (5-HT2A/2C) receptors, and noradrenaline transporters. It shows therapeutic effects against schizophrenia and acute mania.
Zotepine is an atypical antipsychotic.
特点和优势
This compound was developed by Astellas. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
其他说明
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. Z0877.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
基本信息
| 经验(实验)分子式 | C18H18ClNOS |
| 分子量 | 331.86 |
| MDL编号 | MFCD00868143 |
| PubChem化学物质编号 | 329831602 |
| NACRES | NA.77 |
产品性质
| 测定 | >98% (HPLC) |
| 质量水平 | 100 |
| 形式 | powder |
| 颜色 | white to off-white |
| 溶解性 | DMSO: ≥20 mg/mL |
| 创始人 | Astellas |
| 储存温度 | room temp |
| SMILES string | CN(C)CCOC1=Cc2ccccc2Sc3ccc(Cl)cc13 |
| InChI | 1S/C18H18ClNOS/c1-20(2)9-10-21-16-11-13-5-3-4-6-17(13)22-18-8-7-14(19)12-15(16)18/h3-8,11-12H,9-10H2,1-2H3 |
| InChI key | HDOZVRUNCMBHFH-UHFFFAOYSA-N |
安全信息
| 象形图 |   |
| 警示用语： | Warning |
| 危险声明 | H302 - H400 |
| 预防措施声明 | P273 |
| 危险分类 | Acute Tox. 4 Oral - Aquatic Acute 1 |
| 储存分类代码 | 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
