产品说明
一般描述
Cyclic AMP-dependent transcription factor ATF-3 (UniProt P18847; also known as Activating transcription factor 3, cAMP-dependent transcription factor ATF-3) is encoded by the ATF3 gene (Gene ID 467) in human. ATF-3 belongs to the ATF/cAMP-responsive element-binding protein family of basic leucine zipper-type transcription factors. ATF-3 is markedly induced and functions as either a transcriptional activator or repressor in response to LPS, cytokines, hormones, DNA damage, and ER stress in various cell types. ATF3 plays key roles in atherosclerosis and hyperlipidemia, and is reported to negatively regulate the differentiation of adipocyte, chondrocyte, and osteoblast. ATF-3 dysfunction is closely related to various inflammatory diseases and cancer.
特异性
Expected to react with spliced isoforms 1 and 5 (UniProt P18847-1 and P18847-5). Reactivity toward spliced isoforms 2, 3, and 4 (UniProt P18847-2 through P18847-4) of human ATF-3 has not been determined.
免疫原
GST-tagged recombinant human ATF-3 fragment.
应用
Research Category
Neuroscience
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected ATF-3 in 10 µg of RAW264.7 cell lysate.
Research Sub Category
Neurodegenerative Diseases
质量
Evaluated by Western Blotting in THP-1 cell lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected ATF-3 in 10 µg of THP-1 cell lysate.
目标描述
~19 kDa observed.
外形
Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified
储存及稳定性
Stable for 1 year at 2-8°C from date of receipt.
其他说明
Concentration: Please refer to lot specific datasheet.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| eCl@ss | 32160702 |
产品性质
| 生物来源 | human (Recombinant) |
| 质量水平 | 100 |
| 抗体形式 | purified antibody |
| antibody product type | primary antibodies |
| 克隆 | 13A5.1, monoclonal |
| species reactivity | human, mouse |
| technique(s) | western blot: suitable |
| 同位素/亚型 | IgG2bκ |
| NCBI登记号 | NP_001665 |
| UniProt登记号 | P18847 |
| 运输 | wet ice |
| Gene Information | human ... ATF3(467) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
