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Anti-phospho-WAVE-1 (pSer397) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
W2768
规格纯度
~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution
参考价格
6194.6 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

WAS protein family member 1 (WAVE-1) is encoded by the gene mapped to human chromosome 6q21. The encoded protein contains small WH2 acidic domain, a cofilin-like domain, proline-rich domain at C-terminal end and EVH1 domain at N-terminal end. WAVE-1 is active mainly in the brain and lungs, but its mRNA is also found in the placenta, liver and pancreas.

生化/生理作用

WAS protein family member 1 (WAVE-1) functions as a key pro-autophagic protein. The protein has an ability to increase cell survival rate. In addition, it also controls chemoresistance in leukemia cells via Beclin1/ B-cell lymphoma 2 (Bcl)-2 and Beclin1/ phosphatidylinositol 3-kinases (PI3K)-III complex-dependent pathways. The encoded protein enhances ovarian cancer cell proliferation, migration and invasion via activating PI3K/AKT (protein kinase B) and mitogen activated protein kinase p38 (p38MAPK) signaling pathways.

外形

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen ~75 kDa
species reactivityrat (predicted), human (predicted), mouse
浓度~1.5 mg/mL
technique(s)western blot: 1-2 μg/mL using mouse brain extract (S1 fraction)
UniProt登记号Q92558
运输dry ice
储存温度−20℃
Gene Informationhuman ... WASF1(8936)
mouse ... Wasf1(83767)
rat ... Wasf1(294568)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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