产品说明
一般描述
Vesicular glutamate transporter 2 (vGluT2), also known as solute carrier family 17 member 6 (SLC17A6), is encoded by the gene mapped to human chromosome 11p14.3. The encoded protein belongs to the SLC17 family of transporters. vGluT2 is an integral membrane protein with 12 predicted transmembrane domains. It is localized on synaptic vesicles and is expressed mainly in neurons and endocrine terminals.
免疫原
synthetic peptide located near the C-terminus of rat VGLUT2 (amino acids 520-538). The sequence is identical in mouse and human VGLUT2 and has no homology to VGLUT1.
应用
Anti-VGLUT2 (HY-19) antibody produced in rabbit has been used in:
- western blot
- immunolabelling.
- immunohistochemistry.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
包装
200 μL in glass insert
生化/生理作用
Vesicular glutamate transporters (vGluT) play a vital role in the transport of glutamate into secretory vesicles. They are also used as a specific markers to recognize glutamatergic neurons. vGluT2 is considered to be a potent target for reducing glutamatergic neurotransmission. Thus, vGluT2 could be useful for the treatment of neurodegenerative diseases in which chronic excessive glutamate signaling has been involved. It is also used for treating epilepsy and pain.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| MDL编号 | MFCD05865393 |
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 200 |
| 偶联物 | unconjugated |
| 抗体形式 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen 65 kDa |
| species reactivity | rat |
| technique(s) | western blot: 1:2,000 using synaptic vesicle (SV) fraction of rat brain |
| UniProt登记号 | Q9JI12 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... SLC17A6(57084) mouse ... Slc17a6(140919) rat ... Slc17a6(84487) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
