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Urocortin human

品牌
Sigma-Aldrich
CAS
176591-49-4
货号
U4127
规格纯度
≥85% (HPLC), powder
参考价格
6778.41 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

Amino Acid Sequence

Asp-Asn-Pro-Ser-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2

应用

Urocortin human can be used as a test compound for studying the impact of corticotropin-releasing factor (CRF) receptor agonist and antagonist on sleep-wake patterns in conscious rats by using radiotelemetry system.

包装

250 μg in glass bottle

生化/生理作用

Urocortin is a CRF-related neuropeptide having high affinity for CRF2 receptor possess appetite-suppressing effect. Urocortin along with corticotropin-releasing factor (CRF) binding protein (CRF-BP) enhances the free CRF levels in human brain by displacing hCRF from the binding protein.
Binds to CRF receptor types 1, 2α, and 2β; stimulates cAMP accumulation from cells transfected with these receptors. Acts in vitro to release ACTH from rat anterior pituitary cells.

基本信息

经验(实验)分子式C204H337N63O64
分子量4696.24
MDL编号MFCD00802621
NACRESNA.32

产品性质

质量水平200
生物来源human
测定≥85% (HPLC)
形式powder
technique(s)ligand binding assay: suitable
UniProt登记号P55089
储存温度−20℃
Gene Informationhuman ... UCN(7349)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)

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