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Monoclonal Anti-TIS7 antibody produced in mouse

品牌
Sigma-Aldrich
货号
T2576
规格纯度
~2 mg/mL, clone IRT537, purified immunoglobulin, buffered aqueous solution
参考价格
4731.57 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

The tetradecanoylphorbol-13-acetate-induced sequence 7 (TIS7), also known as interferon related developmental regulator 1 (FRD1), is mapped to human chromosome 7q31.1. The gene with 13 exons, spans about 52kb of genomic DNA. The encoded protein consists of 451 amino acids and is expressed in mature neutrophils.

免疫原

synthetic peptide corresponding to amino acids 30-47 of mouse Tis7, conjugated to KLH.

应用

Monoclonal Anti-TIS7 antibody produced in mouse has been used in western blot analysis.

生化/生理作用

Tetradecanoylphorbol-13-acetate-induced sequence 7 (TIS7)/interferon related developmental regulator 1(FRD1) is implicated in regulation of the proliferation and differentiation pathways induced by nerve growth factor (NGF). The encoded protein also plays a vital role in myocyte differentiation, and it modulates the nuclear factor-κB (NF-κB) pathway by influencing the activity of histone deacetylases and forming complexes with the p65 subunit of NFκB. Genetic variations in the gene is associated with the development of various diseases such as sensory/motor neuropathy with ataxia (SMNA), cystic fibrosis, lung disease and myelodysplastic syndrome (MDS). TIS7 is also implicated in regulation of airway inflammation.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD08705605
NACRESNA.41

产品性质

质量水平200
生物来源mouse
偶联物unconjugated
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆IRT537, monoclonal
形式buffered aqueous solution
分子量antigen ~50 kDa
species reactivityhuman, mouse
浓度~2 mg/mL
technique(s)immunocytochemistry: suitable
indirect ELISA: suitable
microarray: suitable
western blot: 0.25-0.5 using extracts of COS7 cells transfected with mouse Tis7
同位素/亚型IgG2a
UniProt登记号O00458
运输dry ice
储存温度−20℃
Gene Informationhuman ... IFRD1(3475)
mouse ... Ifrd1(15982)
rat ... Ifrd1(29596)

Sigma-Aldrich

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