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Tissue Inhibitor of Metalloproteinase-3 human

品牌
Sigma-Aldrich
货号
T1327
规格纯度
recombinant, expressed in NSO cells, >95% (SDS-PAGE)
参考价格
8737.56 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Tissue inhibitor of metalloproteinases 3 (TIMP3) is localized in the extracellular matrix (ECM) of epithelial cells associated with kidneys, eyes and lungs. It is majorly secreted in retinal pigment epithelium (RPE). TIMP3 gene is mapped to human chromosome 22q12.3 and is a CLOCK-dependent diurnal gene. TIMP proteins display a three-lobed structure and have conserved cysteine residues.

生化/生理作用

Tissue inhibitor of metalloproteinases 3 (TIMP3) is a matrix metalloproteinase inhibitor. TIMP proteins comprise the N-terminal region, which aids in the matrix metalloproteinase interaction. The C-terminal region is crucial for extracellular matrix (ECM) interaction. Elevated expression of TIMP3 favors apoptosis in cancer types. Its interaction with the vascular endothelial growth factor (VEGFR-2) leads to the regulation of angiogenesis. TIMP3 also aids in protection against ultra-violet (UV)-induced cellular responses. Missense mutations in the TIMP3 gene are implicated in Sorsby′s fundus dystrophy (SFD). Mutations in the TIMP3 gene also leads to increased accumulation of the protein resulting in the thickening of the Bruch membrane. This, in turn, reduces membrane permeability towards nutrients and metabolites.
The TIMPs are endogenous inhibitors of the matrix metalloproteinases (MMPs). TIMP-3 inhibits ADAM-17 (TACE) at nanomolar concentrations and also inhibits other metalloproteinases (sheddases) that mediate the shedding of soluble receptors and other proteins from the surface of cells.

外形

Lyophilized from a 0.2 μm filtered solution in 25 mM Tris and 0.15 M sodium chloride, pH 7.5.

分析说明

The biological activity is measured by its ability to inhibit human MMP-2 hydrolysis of a peptide substrate.

基本信息

MDL编号MFCD02266291
NACRESNA.32

产品性质

质量水平100
生物来源human
重组expressed in NSO cells
测定>95% (SDS-PAGE)
形式lyophilized powder
分子量apparent mol wt ~30 kDa
technique(s)inhibition assay: suitable
UniProt登记号P35625
储存温度−20℃
Gene Informationhuman ... TIMP3(7078)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Gloves

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