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Thimet Oligopeptidase from Bacillus licheniformis

西梅脱寡肽酶 来源于地衣芽孢杆菌

品牌
Sigma-Aldrich
货号
T7705
包装型号
规格纯度
参考价格
4890.28 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Thimet oligopeptidase is considered essential in the degradation of collagen in collaboration with collagenolytic enzymes. Thimet oligopeptidase (TOP) is a neuropeptidase involved in the hydrolysis of gonadotropin-releasing hormone, a key component of the hypothalamic-pituitary-gonadal axis.

应用

Thimet oligopeptidase can be used for the degradation of collagen in combination with collagenases. It can also be used for the hydrolysis of neuropeptides such as bradykin, neurotensin, and amyliod-β-peptide. Thimet oligopeptidase has been used in a study to investigate the effect of acute cocaine administration in male rats on TOP specific activity and mRNA levels in prosencephalic brain areas related with the reward circuitry: ventral striatum, hippocampus, and frontal cortex.

制备说明

This enzyme has been affinity chromatographically purified using a niquel affinity column. It contains a 6-Histidine tag in its C-terminus.

A working solution of this enzyme can be prepared in 20 mM phosphate buffered saline solution, pH 7.0, or sterile and deionized water, pH 7.0.

基本信息

酶学委员会(EC)编号3.4.24.15 ( BRENDA | IUBMB )
NACRESNA.54

产品性质

质量水平200
重组expressed in E. coli
形式powder
分子量 ~77 kDa
储存温度−20℃

安全信息

象形图GHS07
警示用语:Warning
危险声明H315 - H332
危险分类Acute Tox. 4 Inhalation - Skin Irrit. 2
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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