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Terameprocol

品牌
Sigma-Aldrich
CAS
24150-24-1
货号
T3455
规格纯度
≥98% (HPLC)
参考价格
870.88 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

包装

10, 50 mg in glass bottle

生化/生理作用

Terameprocol is a synthetic derivative of NDGA, a non-selective lipoxygenase inhibitor. It inhibits Sp1 transcription factor binding at the HIV long terminal repeat promoter and at the α-ICP4 promoter, a gene essential for HSV replication, with IC50 values of 11 and 43.5 μM respectively. TMNDGA induces growth arrest and apoptosis by suppressing Sp1-dependent Cdc2 and survivin gene expression giving rise to its antitumorigenic activity. The in vivo growth of xenografts in numerous human tumor types was suppressed upon treatment with TMNDGA It also inhibits the growth of murine and human melanomas and human colon cancer in vivo without causing other tissue toxicity.
Terameprocol is known to reduce angiogenesis1.

制备说明

Terameprocol is soluble in DMSO at a concentration that is greater than or equal to 10 mg/ml.

基本信息

经验(实验)分子式C22H30O4
分子量358.47
MDL编号MFCD11113155
PubChem化学物质编号329826768
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white to off-white
溶解性DMSO: ≥10 mg/mL
储存温度−20℃
SMILES stringCOc1ccc(C[C@H](C)[C@H](C)Cc2ccc(OC)c(OC)c2)cc1OC
InChI1S/C22H30O4/c1-15(11-17-7-9-19(23-3)21(13-17)25-5)16(2)12-18-8-10-20(24-4)22(14-18)26-6/h7-10,13-16H,11-12H2,1-6H3/t15-,16+
InChI keyORQFDHFZSMXRLM-IYBDPMFKSA-N

安全信息

象形图GHS09
警示用语:Warning
危险声明H410
预防措施声明P273 - P501
危险分类Aquatic Acute 1 - Aquatic Chronic 1
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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