产品说明
一般描述
Chemical structure: pyrimidine
应用
Trimethoprim is primarily used as an antibacterial agent. It has dihydrofolate reductase inhibitor activity with selectivity for the prokaryote enzyme. It is used clinically to treat urinary tract infections, mild acute prostatitis, recurrent cystitis, asymptomatic bacteriuria during pregnancy and respiratory tract infections. Trimethoprim lactate salt is used as a selection agent.
包装
250 mg in glass bottle
生化/生理作用
The combination of trimethoprim and sulfamethoxazole interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to prokaryote-specific dihydrofolate reductase (DHFR) and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis.
其他说明
Keep container tightly closed in a dry and well-ventilated place.
基本信息
| 经验(实验)分子式 | C14H18N4O3 · C3H6O3 |
| 分子量 | 380.40 |
| EC 号 | 245-533-1 |
| MDL编号 | MFCD00171722 |
| PubChem化学物质编号 | 329826610 |
| NACRES | NA.85 |
产品性质
| 质量水平 | 200 |
| 测定 | ≥98% |
| 形式 | powder |
| 储存条件 | (Keep container tightly closed in a dry and well-ventilated place.) |
| 颜色 | white |
| 溶解性 | H2O: soluble 20 mg/mL |
| 作用机制 | DNA synthesis | interferes enzyme | inhibits |
| 抗生素抗菌谱 | Gram-negative bacteria Gram-positive bacteria mycobacteria |
| 储存温度 | 2-8℃ |
| SMILES string | CC(O)C(O)=O.COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC |
| InChI | 1S/C14H18N4O3.C3H6O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-2(4)3(5)6/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2,4H,1H3,(H,5,6) |
| InChI key | IIZVTUWSIKTFKO-UHFFFAOYSA-N |
安全信息
| 象形图 |   |
| 警示用语： | Danger |
| 危险声明 | H301 - H361d |
| 预防措施声明 | P202 - P264 - P270 - P280 - P301 + P310 - P405 |
| 危险分类 | Acute Tox. 3 Oral - Repr. 2 |
| 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
