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(1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid hydrate

品牌
Sigma-Aldrich
CAS
182485-36-5
货号
T200
规格纯度
≥97% (HPLC), solid
参考价格
3444.35 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

(1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid hydrate has also been used as γ-aminobutyric acid C (GABAc) blocker in retinal ganglion cells.
TPMA has been used as a GABAC receptor antagonist to study the role of inner retinal inhibition in midget ganglion cells. TPMPA has also been used to study the role of GABAC receptor antagonists in suppressing orientation selectivity in ganglion cells.

包装

10, 50 mg in glass bottle

生化/生理作用

TPMPA is a hybrid of isoguvacine and 3-APMPA designed to retain affinity for GABAC receptors but not to interact with GABAA or GABAB receptors. Electrical assays show that TPMPA is a competitive antagonist of cloned human mu 1 GABAC receptors expressed in Xenopus laevis oocytes (Kb approx. 2 μM). TPMPA is >100-fold weaker as an inhibitor of rat brain GABAA receptors expressed in oocytes (Kb approx. 320 μM) and has only weak agonist activity on GABAB receptors assayed in rat hippocampal slices (EC50 approx. 500 μM). TPMPA may be used to investigate GABAC receptor function in the outer retina and in any other areas of the nervous system in which these types of receptor are present.

特点和优势

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAC Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

制备说明

(1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid (TPMPA) hydrate is soluble in water at 16 mg/ml, but is insoluble in DMSO.

法律信息

Sold in the USA under exclusive license from the University of California.

基本信息

经验(实验)分子式C6H12NO2P · xH2O
分子量161.14 (anhydrous basis)
PubChem化学物质编号24278172
NACRESNA.77

产品性质

质量水平100
测定≥97% (HPLC)
形式solid
颜色 white to off-white
溶解性H2O: 16 mg/mL
DMSO: insoluble
SMILES string[H]O[H].CP([O-])(=O)C1=CC[NH2+]CC1
InChI1S/C6H12NO2P.H2O/c1-10(8,9)6-2-4-7-5-3-6;/h2,7H,3-5H2,1H3,(H,8,9);1H2
InChI keyGXVWAQPRAQORGS-UHFFFAOYSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)

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