产品介绍：
产品说明
应用
SIB 1757 may be used in mGluR5 metabotropic glutamate receptor-mediated cell signaling studies.
生化/生理作用
SIB 1757 is a highly selective mGluR5 metabotropic glutamate receptor antagonist. It non-competitively inhibits glutamate-induced increase in Ca2+ at human metabotropic glutamate receptor 1 (hmGluR1).1 Inhibition of mGlu5 receptor renders protection to neurons2 against methamphetamine-induced oxidative damage.3
特点和优势
This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
基本信息
| 经验(实验)分子式 | C12H11N3O |
| 分子量 | 213.24 |
| MDL编号 | MFCD00506102 |
| PubChem化学物质编号 | 24278717 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥99% (HPLC) |
| 形式 | crystalline |
| 颜色 | red |
| SMILES string | Cc1ccc(O)c(\N=N\c2ccccc2)n1 |
| InChI | 1S/C12H11N3O/c1-9-7-8-11(16)12(13-9)15-14-10-5-3-2-4-6-10/h2-8,16H,1H3/b15-14+ |
| InChI key | LOCPVWIREQIGNQ-CCEZHUSRSA-N |
| Gene Information | human ... GRM1(2911), GRM5(2915) |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H315 - H319 - H335 |
| 预防措施声明 | P302 + P352 - P305 + P351 + P338 |
| 危险分类 | Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 |
| 靶器官 | Respiratory system |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
