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Anti-SORL1 (C-terminal) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
S9200
规格纯度
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
参考价格
7462.42 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Sortilin related receptor 1 (SORL1), a multifunctional protein, is also known as SorLA-1, LR11, LRP9 and gp250. It is a type-I transmembrane protein highly expressed in neurons. This protein belongs to the low-density lipoprotein receptor family. It contains a transmembrane domain, a large extracellular domain and a short cytoplasmic tail. SORL1 gene is located on human chromosome 11q 23/24. This mosaic receptor contains a domain that shares similarity with the vacuolar protein sorting 10 (VPS10) and with the low-density lipoprotein receptor (LDLR) family of proteins.

特异性

Anti-SORL1 (C-terminal) specifically recognizes rat SORL1.

应用

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Anti-SORL1 (C-terminal) antibody produced in rabbit has been used in immunoblotting.

生化/生理作用

Sortilin related receptor 1 (SORL1) protein plays a key role in intracellular protein transport and endocytosis, cell signaling and the proliferation and migration of smooth muscle cells. It acts as a receptor for lipoproteins, glial cell-line-derived neurotrophic factor (GDNF) and platelet-derived growth factor (PDGF). Expression of this protein is developmentally regulated, with high transcript levels found during morphogenesis. SORLA is involved in development of atherosclerosis and in Alzheimer′s disease (AD). It mediates the uptake of apolipoprotein E (ApoE)-rich lipoproteins and is markedly induced in atheroma. SORL1 is known to play a regulating role in trafficking and processing of the amyloid precursor protein (APP) in neuronal cells. In the Golgi, SorLA/LR11 binding of APP leads to sequestration of APP and thereby it blocks the processing to the beta-amyloid peptide.

外形

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

储存及稳定性

Store at –20 ℃. For continuous use, the product may be stored at 2–8 ℃ for up to one month. For extended storage, freeze in working aliquots at –20 ℃. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen ~250 kDa
species reactivityhuman, rat
包装antibody small pack of 25 μL
浓度~1.0 mg/mL
technique(s)western blot: 1-2 μg/mL using rat cerebellum (S1 fraction)
UniProt登记号Q92673
运输dry ice
储存温度−20℃
Gene Informationhuman ... SORL1(6653)
mouse ... Sorl1(20660)
rat ... Sorl1(300652)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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