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Sphingomyelinase from Bacillus cereus

鞘磷酯酶 来源于蜡样芽胞杆菌

品牌
Sigma-Aldrich
CAS
9031-54-3
货号
S9396
规格纯度
buffered aqueous glycerol solution, ≥100 units/mg protein (Lowry)
参考价格
2575.56 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Sphingomyelinase (SMase) is a hydrolase, of 34.2 kDa and its active site contain as a minimum of two magnesium atoms.

应用

Sphingomyelinase has been used in a study to assess the interaction of actin with the HIV-1 accessory protein Nef. Sphingomyelinase has also been used in a study to investigate X-ray scattering as a quality-control tool for liposomal drug-delivery systems.
Sphingomyelinase from Bacillus cereus has been used:

  • in the study to analyse the effect of sphingomyelinase on Rubella virus infectivity in cell lines
  • in lipoprotein modification for the generation of cholesterol crystals in vitro
  • to aggregate LDL (low-density lipoprotein)

生化/生理作用

启动形成基于鞘磷脂的第二信使。激活 MAPK(丝裂原活化蛋白激酶)和 SAPKs(压力激活蛋白激酶);从鞘磷脂生成神经酰胺。
Sphingomyelin phosphodiesterase (SMPD) participates in the metabolic reactions comprising sphingomyelin. SMPD has the ability to prevent colorectal carcinoma and colitis.

单位定义

One unit will hydrolyze 1.0 μmole of TNPAL-sphingomyelin per min at pH 7.4 at 37 ℃.

外形

Solution in 50% glycerol containing 50 mM Tris-HCl, pH 7.5.

基本信息

酶学委员会(EC)编号3.1.4.12 ( BRENDA | IUBMB )
MDL编号MFCD00132362
NACRESNA.54

产品性质

形式buffered aqueous glycerol solution
质量水平200
specific activity≥100 units/mg protein (Lowry)
分子量 34.2 kDa
异质活性Phospholipase C ≤1%
储存温度2-8℃
Gene InformationBacillus cereus ATCC 10987 ... spH(2751530)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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