产品介绍：
产品说明
应用
SB 204741 has been used as a 5-hydroxytryptamine receptor 2B (Htr2B) antagonist:
- to inhibit Htr2b signaling to test its effect on hepatic stellate cell (HSC) activation in three-month-old adult zebrafish
- to test its effect on the inhibition of fluoxetine effects in depressive-like behavioral studies in mice
- to test its effect in reducing scratching behavior evoked by sertraline in mice
包装
10, 50 mg in glass bottle
生化/生理作用
SB 204741 reduces the synaptic facilitation induced by the low dose of buprenorphine in spinal C-fiber synapses.
5-HT2B serotonin receptor antagonist.
特点和优势
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
法律信息
Sold for research purposes under agreement from GlaxoSmithKline
基本信息
| 经验(实验)分子式 | C14H14N4OS |
| 分子量 | 286.35 |
| MDL编号 | MFCD00923644 |
| PubChem化学物质编号 | 24278321 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | >98% (HPLC) |
| 形式 | solid |
| 颜色 | off-white to tan |
| 溶解性 | DMSO: soluble >20 mg/mL |
| 创始人 | GlaxoSmithKline |
| 储存温度 | 2-8℃ |
| SMILES string | Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1 |
| InChI | 1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19) |
| InChI key | USFUFHFQWXDVMH-UHFFFAOYSA-N |
| Gene Information | human ... DRD2(1813), DRD3(1814), DRD5(1816), HTR1E(3354), HTR2A(3356), HTR2B(3357), HTR2C(3358) rat ... Adra1a(29412), Gabra2(29706), Htr1a(24473), Htr2b(29581), Htr3a(79246) |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H315 - H319 - H335 |
| 预防措施声明 | P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338 |
| 危险分类 | Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 |
| 靶器官 | Respiratory system |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
