Rottlerin-CAS 82-08-6-Calbiochem

产品说明

一般描述

A cell-permeable and reversible inhibitor of protein kinase C δ (PKCδ, IC₅₀ = 3-6 µM) and PKC_Θ isozymes. Also inhibits PKC_α, PKC_β, and PKC_γ isoforms, but with significantly reduced potency (IC₅₀ = 30-42 µM). Has reduced inhibitory activity on PKC_ε, PKC_η, and PKC_ξ (IC₅₀ = 80-100 µM). Also known to inhibit CaM kinase III (IC₅₀ = 5.3 µM).
A cell-permeable and reversible protein kinase C inhibitor that exhibits greater selectivity for PKC_δ (IC₅₀ = 3-6 µM) and PKC_θ. Inhibits the PKC_α, PKC_β, and PKC_γ isoforms, but with significantly reduced potency (IC₅₀ = 30-42 µM). Has reduced inhibitory activity on PKC_ε, PKC_η, and PKC_ζ (IC₅₀ = 80-100 µM). Also known to inhibit CaM kinase III (IC₅₀ = 5.3 µM).

包装

10 mg in Plastic ampoule

生化/生理作用

Cell permeable: yes
Product does not compete with ATP.
Primary Target
PKCδ
Reversible: yes
Target IC₅₀: 3-6 µM against PKCδ; 5.3 µM against CaM kinase III

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Villalba, M., et al. 1999. J. Immunol. 163, 5813.
Gschwendt, M., et al. 1994. Biochem. Biophys. Res. Commun. 199, 93.
Gschwendt, M., et al. 1994. FEBS Lett.338, 85.
Gschwendt, M., et al. 1984. Cancer Lett.25, 177.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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