Anti-Tau Antibody, clone Tau 12

产品说明

一般描述

Microtubule Associated Proteins, or MAPS, bind to the tubulin subunits of microtubule structures and regulate their functional stability. In the cell MAPs bind to monomer and multimerized tubulin. MAP binding to multimerized tubulin further stabilizes the formation of higher order microtubulin structures. MAP binding to microtubule structures is mediated through phosphorylation through Microtubule Affinity Regulated Kinase (MARK). Phosphorylation releases MAPs bound to microtubules, destabilizing the structure, driving it toward disassembly. There are predominately two MAP types, I, II. Type II MAP includes MAP2, MAP4, and tau and are found in nervous tissue. Six tau isoforms exist in brain tissue, and they are distinguished by their number of binding domains. Three isoforms have three binding domains and the other three have four binding domains. The binding domains are located in the carboxy-terminus of the protein and are positively-charged (allowing it to bind to the negatively-charged microtubule). The isoforms with four binding domains are better at stabilizing microtubules than those with three binding domains.

特异性

Reactivity with other species has not been determined.
Cat. # MAB2241 recognizes the N-terminus region of Tau.

免疫原

KLH conjugated synthetic linear peptide.
Epitope: N-terminus

应用

Research Category
Neuroscience
Anti-Tau Antibody, clone Tau 12 is an antibody against Tau for use in WB.
Research Sub Category
Neurodegenerative Diseases

质量

Western Blot:

目标描述

50-68 kDa

联系

Replaces: MAB10417

外形

Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8ºC from date of receipt.

分析说明

Control
Human brain tissue lysate.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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