产品说明
一般描述
Ribosomal protein S6 kinase α-1 (RPS6KA1) or RSK1 is a member of the RSK (ribosomal S6 kinase) family that consists of growth factor-regulated serine/threonine kinases. RSK1 contains 2 nonidentical kinase catalytic domains. RSK1 encodes a predicted 735-amino acid protein containing 2 distinct consensus ATP-binding site sequences. RSK1 transcript is present in lymphocytes, skeletal muscle, liver, and adipose tissue.
生化/生理作用
Ribosomal S6 kinases (RSKs) are implicated in the activation of the mitogen-activated kinase (MAPK) cascade and the stimulation of cell proliferation and differentiation. The protein suppresses the pro-apoptotic function of BAD by phosphorylating it. RSK1 phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signaling pathway.
外形
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
法律信息
PRECISIO is a registered trademark of sigma-aldrich Co. LLC
基本信息
| NACRES | NA.32 |
产品性质
| 质量水平 | 200 |
| 重组 | expressed in baculovirus infected Sf9 cells |
| 产品线 | PRECISIO® Kinase |
| 测定 | ≥70% (SDS-PAGE) |
| 形式 | buffered aqueous glycerol solution |
| specific activity | 159-215 nmol/min·mg |
| 分子量 | ~108 kDa |
| UniProt登记号 | Q15418 |
| 运输 | dry ice |
| 储存温度 | −70℃ |
| Gene Information | human ... RPS6KA1(6195) |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
