产品说明
一般描述
Rab27 (Ras-related protein) is a member of the Rab family of small guanosine triphosphatases (GTPases). Rab27 is widely expressed in non-neuronal regulated secretory cells, including exocrine, endocrine, ovarian, and hematopoietic cells.
Rab27A (Ras-related protein) belongs to the Rab family of small GTPase proteins. It is located on chromosome 15q21.
免疫原
synthetic peptide corresponding to amino acid residues 45-57 of human RAB27A, with an added cysteine, conjugated to KLH. The corresponding sequence differs by one amino acid in rat and mouse Rab27A and by 2 amino acids in human RAB27B.
应用
Anti-Rab27 (N-terminal) antibody has been used in immunoblotting, immunofluorescence.
生化/生理作用
In humans, Rab27A (Ras-related protein) plays important roles in the development of cancers. It is considered as a prognostic biomarker for CRC (colorectal cancer) patients. It may participate in the transfer of protein and signal transduction mediated by GTPase. Rab27 mutation is linked with Griscelli syndrome type 2. It is also responsible for the innate immune resistance against invading microorganisms.
Rab27 (Ras-related protein) regulates the exocytosis of these cell-specific store organelles, using multiple organelle-specific effector proteins, such as granuphilin and melanophilin.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 200 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen ~25 kDa |
| species reactivity | rat, human |
| 浓度 | ~1.5 mg/mL |
| technique(s) | indirect immunofluorescence: 5-10 μg/mL using rat NRK cells fixed and permeabilized with 4% paraformaldehyde followed by 0.4% saponin western blot: 2-5 μg/mL using whole extract of human A431 cells |
| UniProt登记号 | P51159 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... RAB27A(5873) rat ... Rab27a(50645) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
