产品说明
应用
Ro 41-0960 has been used as an inhibitor of catechol-O-methyl-transferase in synaptosome membrane preparations and 3T3-L1 adipocytes. It has also been used as a catechol-O-methyl-transferase inhibitor to treat corpus striatum samples to test its effect on dopamine metabolism.
包装
25, 100 mg in poly bottle
生化/生理作用
Ro 41-0960 is a specific and synthetic inhibitor of the enzyme catechol-O-methyl-transferase (COMT). It binds to the catalytic site and triggers the inhibition of the methylation property of COMT. Ro 41-0960 is effective on uterine leiomyoma lesions and uterine fibroids.
特点和优势
This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
注意
Store tightly sealed at 4 ℃, protected from exposure to light.
基本信息
| 经验(实验)分子式 | C13H8FNO5 |
| 分子量 | 277.20 |
| MDL编号 | MFCD00078597 |
| PubChem化学物质编号 | 24278193 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 形式 | solid |
| 储存条件 | protect from light |
| 颜色 | yellow |
| 溶解性 | H2O: slightly soluble <0.7 mg/mL 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.0 mg/mL ethanol: soluble |
| 储存温度 | 2-8℃ |
| SMILES string | Oc1cc(cc(c1O)[N+]([O-])=O)C(=O)c2ccccc2F |
| InChI | 1S/C13H8FNO5/c14-9-4-2-1-3-8(9)12(17)7-5-10(15(19)20)13(18)11(16)6-7/h1-6,16,18H |
| InChI key | RQPAUNZYTYHKHA-UHFFFAOYSA-N |
| Gene Information | human ... COMT(1312) |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
