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Goat Anti-Human IgG Antibody, HRP conjugate

品牌
Sigma-Aldrich
货号
AP309P
规格纯度
1.0 mg/mL, Chemicon®
参考价格
6019.83 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Immunoglobulin G (IgG) is the main type of glycoprotein antibody found in human serum, secreted by the B cells. It is found in blood and comprises four polypeptide chains, made of two identical 50 kDa γ heavy (H) chains and two identical 25 kDa κ or λ light (L) chains. These chains are inter-linked by di-sulfide bonds. IgG exists in four isotypes IgG1, IgG2, IgG3 and IgG4. IgG has the longest serum half-life compared to other immunoglobulins.

特异性

Specific for human IgG gamma chain. The cross-reactivities of anti-human IgG (gamma) antibody are tested in an ELISA. Minimal cross-reactivity to light chains.

The reagent is an affinity purified antibody from goat. The purified antibody is conjugated to horseradish peroxidase (HRP) and stabilized in buffer.

应用

ELISA: 1:3,000

Immunohistochemistry: 1:200-1:500 (1-4)

Immunocytochemistry: 1:200-1:500 (1-4)

Western Blot, chromogenic: 1:200-1-500

Western Blot, chemiluminescent: 1:2,000-1:5,000

Optimal working dilutions must be determined by the end user.

生化/生理作用

Immunoglobulin G (IgG) initiates the classical pathway of the complement system. It neutralizes virus particles and toxins. IgG plays a vital role in antibody-dependent cell-mediated cytotoxicity (ADCC) and might be associated with allergy. Maternal IgG is transferred to the fetus through the placenta that is crucial for the immune defense of the neonate against infections. Digestion of IgG by papain results in the production of fragment antigen-binding (Fab). Pepsin digestion of IgG leads to the generation of fragment crystallizable (Fc). Levels of IgG in severe acute respiratory syndrome coronavirus (SARS-CoV)-2 infected patients can be used as a potential tool to evaluate the severity and prognosis of coronavirus disease 2019 (COVID-19).

外形

ImmunoAffinity Purified

储存及稳定性

The undiluted antibody is stable at 2-8°C for 12 months. Do not store in a diluted format. DO NOT FREEZE.

法律信息

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.46

产品性质

质量水平100
生物来源goat
偶联物peroxidase conjugate
抗体形式affinity purified immunoglobulin
antibody product typesecondary antibodies
克隆polyclonal
形式lyophilized
species reactivityhuman
manufacturer/tradenameChemicon®
浓度1.0 mg/mL
technique(s)ELISA: suitable
western blot: suitable
同位素/亚型IgG
运输wet ice
储存温度2-8℃

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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