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Anti-Synuclein α Antibody

品牌
Sigma-Aldrich
货号
AB5038P
规格纯度
Chemicon®, from rabbit
参考价格
6202.75 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

alpha -Synuclein is a small (140-amino acid) cytoplasmic protein of unclear function that is enriched in presynaptic terminals and is the precursor protein of a nonamyloid beta component of senile plaques in Alzeheimer′s Disease (AD). alpha -Synuclein is located predominantly in the presynaptic nerve terminals in the brain but is also found in low concentrations in all tissues except liver. Recent studies have shown that abnormal aggregation and accumulation of synaptic proteins, including alpha-Synuclein might be associated with plaque formation in AD and seems to be a major component of Lewy bodies in dementia with Lewy bodies (DLB). It has also been identified in the Glial Cytoplasmic Inclusions (GCIs) found in Multiple System Atrophy (MSA).

特异性

Recognizes Alpha-synuclein. The immunizing peptide was chosen to reduce cross-reactivity of AB5038 with beta-synuclein to a minimum. Immunohistochemical and Western blot analysis of human brain indicates a high level of specificity.

免疫原

Human alpha-synuclein residues 111-131 coupled to KLH. The peptide sequence is N-GILEDMPVDPDNEAYEMPSEEC-C. This peptide is available for use in blocking studies (Cat. No. AG239).

应用

Western blot: 1:1000-1:2000

Immunohistochemistry: 1:1000-1:2000 on paraffin sections, 1:4000-1:12,000 on frozen sections..

Optimal working dilutions must be determined by end user.
This Anti-Synuclein Antibody, α is validated for use in IH(P), WB for the detection of Synuclein.
Research Category
Neuroscience
Research Sub Category
Neurodegenerative Diseases

目标描述

14-19 kDa

联系

Replaces: 04-1053

外形

ImmunoAffinity Purified
Affinity Purified immunoglobulin. Lyophilized, no preservatives. Reconstitute with 20 μL of sterile distilled water. Centrifuge to remove any residue.

储存及稳定性

Maintain at -20 in undiluted aliquots for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (1:1) can be added for additional stability.

分析说明

Control
Brain tissue

法律信息

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

生物来源rabbit
质量水平100
抗体形式affinity purified immunoglobulin
antibody product typeprimary antibodies
克隆polyclonal
纯化方式affinity chromatography
species reactivityhuman, rat
manufacturer/tradenameChemicon®
technique(s)immunohistochemistry: suitable (paraffin)
western blot: suitable
NCBI登记号NM_000345.2
NM_007308.1
UniProt登记号P37840
运输dry ice
Gene Informationhuman ... SNCA(6622)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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