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Monoclonal Anti-PINCH-1 antibody produced in mouse

品牌
Sigma-Aldrich
货号
P8996
规格纯度
clone PINCH-C58, purified immunoglobulin, buffered aqueous solution
参考价格
4731.57 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Monoclonal Anti-PINCH-1 (mouse IgG1 isotype) is derived from the hybridoma PINCH-C58 produced by the fusion of mouse myeloma cells (NS1 cells) and splenocytes from BALB/c mice immunized with a peptide of human PINCH1, conjugated to KLH. LIM and senescent cell antigen-like-containing domain protein 1 (LIMS1) or particularly interesting new Cys-His protein 1 (PINCH-1) is widely expressed. It has five LIM domains. It has leucine-rich nuclear export signal (NES) and nuclear localization signal (NLS) at the C-terminus. Human PINCH-1 and 2 are encoded by two different genes that are 82% identical in their amino acid sequence.

免疫原

peptide corresponding to amino acids 281-299 of human PINCH-1, conjugated to KLH.

应用

Monoclonal Anti-PINCH-1 antibody produced in mouse has been used in:

  • enzyme linked immunosorbent assay (ELISA)
  • immunoblotting
  • immunoprecipitation
  • co-immunoprecipitation

生化/生理作用

The interaction with PINCH proteins (PINCH-1 and 2) is important for localization of integrin linked kinase protein to cell matrix contact sites. It plays a key role in cell−matrix adhesion. PINCH2 is co-expressed and co-localized with PINCH-1/ILK complex. PINCH1 interacts with Wilms tumor 1 protein (WT1) in podocytes. Elevated expression of PINCH1 is observed in human laryngeal carcinoma.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD06798713
NACRESNA.41

产品性质

质量水平200
生物来源mouse
偶联物unconjugated
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆PINCH-C58, monoclonal
形式buffered aqueous solution
分子量antigen ~37 kDa
species reactivityrat, bovine, hamster, mouse, human, canine, monkey
technique(s)immunoprecipitation (IP): suitable
indirect ELISA: suitable
western blot: 1-2 μg/mL using total cell extract from 293T cells
同位素/亚型IgG1
UniProt登记号P48059
运输dry ice
储存温度−20℃
Gene Informationhuman ... LIMS1(3987)
mouse ... Lims1(110829)
rat ... Gcc2(309798)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKnwg
闪点(F)Not applicable
闪点(C)Not applicable

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