Anti-PRMT4 antibody produced in rabbit

产品说明

一般描述

Protein arginine methyltransferase 4 (PRMT4), which is also known as coactivator associated arginine methyltransferase 1 (CARM1), is part of the protein arginine methyltransferase (PRMT) family. The gene encoding this protein is localized on human chromosome 19p13.2.

免疫原

synthetic peptide corresponding to amino acids 48-63 of human PRMT4 conjugated to KLH via a C-terminal added lysine residue. The sequence is conserved in mouse.

应用

Anti-PRMT4 antibody produced in rabbit has been used for Western Blotting and immunofluorescence.

包装

200 μL in glass insert

生化/生理作用

Protein-arginine methyl transferase 4 (PRMT4) plays a central role in upregulation of transcription by nuclear hormone receptors (NRs).
Protein arginine methyltransferase 4 (PRMT4) methylates arginine residues of histones and other proteins and thus has a role in modulation of gene expression. The protein also methylates histone acetyl transferases. It has been shown to associate with Mi2α, a chromatin remodeler. It also associates with nuclear factor κB (NF-κB), estrogen receptor and tumor suppressor p53 and is recruited to specific target genes. PRMT4 has a role in pre-mRNA splicing and DNA damage response. The protein has been shown to be upregulated in liver, prostate and breast cancers.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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