产品介绍：
产品说明
一般描述
VPC 32179 is devoid of agonist activity at the human LPA2 and LPA3 receptors and behaves as a competitive antagonist at the LPA3 receptor. However, VPC 32179 has been found to have partial agonist activity in a cell migration assay; this is most likely due to activity at the LPA1 receptor.
应用
VPC 32179 (R) has been used:
- to examine the roles of lysophosphatidic acid (LPA) receptor subtypes in related adhesion focal tyrosine kinase (RAFTK) activation
- as a LPA3 receptor antagonist to inhibit LPA-induced protein kinase C (PKC) activity in cultured muscle cells
- as a LPA1 competitive antagonist to block LPA-induced proliferation of mast cells
生化/生理作用
VPC 32179 exhibits partial agonist activity in cell migration assay, which is due to the activity at lysophosphatidic acid 1 (LPA1) receptor. It lacks agonist activity at the human LPA2 and LPA3 receptors. VPC 32179 exhibits competitive antagonistic activity at the LPA3 receptor.
包装
5 mL Amber Glass Screw Cap Vial (857350P-1mg)
基本信息
| 经验(实验)分子式 | C33H54N3O6P |
| 分子量 | 619.77 |
| NACRES | NA.25 |
产品性质
| 测定 | >99% (TLC) |
| 形式 | powder |
| 包装 | pkg of 1 × 1 mg (857350P-1mg) |
| manufacturer/tradename | Avanti Polar Lipids 857350P |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| SMILES string | O=C(CCCCCCC/C=C\CCCCCCCC)N[C@H](CC1=CC=C(OCC2=CC=CC=N2)C=C1)COP(O)([O-])=O.[NH4+] |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
