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Phosphoinositide 3-kinase p110γ human

品牌
Sigma-Aldrich
货号
P8615
规格纯度
≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution
参考价格
9755.52 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Phosphatidylinositol 3-kinase p110γ /phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit γ (PIK3CG) gene, with 12 exons spanning 43 kb on genomic DNA, is mapped to human chromosome 7q22.3. PIK3CG belongs to the family of genes coding for enzymes that phosphorylate the 3′-hydroxyl of phosphatidylinositol.

生化/生理作用

PI 3-kinases have been implicated in diverse cellular responses triggered by mammalian cell surface receptors. Inhibits NF-κB, AP-1, and STAT1α mediated gene expression induced by IFN-γ resulting in inhibition of COX-2 and NOS ll (iNOS) expression.
Phosphatidylinositol 3-kinase p110γ is implicated in the development of eosinophilic inflammation. Thus, inhibition of PI3Kγ expression can be considered as a potential therapeutic method for treating eosinophil-related diseases, including asthma. Knockdown of PIK3CG gene inhibits the PI3K-Akt/PKB signaling pathway, which is essential for tumorigenesis and the progression of colorectal cancers. Mutation in the gene is associated with the development of autistic disorder.
PI 3-kinases have been implicated in diverse cellular responses triggered by mammalian cell surface receptors. Inhibits NF-κB, AP-1, and STAT1α mediated gene expression induced by IFN-γ resulting in inhibition of COX-2 and NOS ll (iNOS) expression.

单位定义

1 unit will transfer 1 nmol of phosphate/min, using phosphatidylinositol as substrate.

外形

Solution in 10 mM HEPES, pH 7.5, 100 mM NaCl, 0.5 mM MgCl2, 50% glycerol.

基本信息

MDL编号MFCD03457993
NACRESNA.32

产品性质

质量水平200
重组expressed in baculovirus infected insect cells
测定≥95% (SDS-PAGE)
形式buffered aqueous glycerol solution
specific activity~4.5 units/mg protein
UniProt登记号P48736
运输dry ice
储存温度−70℃
Gene Informationhuman ... PIK3CG(5294)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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