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Anti-phospho-Myristoylated Alanine-Rich Protein Kinase C Substrate (pSer152/156) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
P0370
规格纯度
affinity isolated antibody, buffered aqueous glycerol solution
参考价格
4731.57 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

The proteins of myristoylated alanine-rich C kinase substrate (MARCKS) family are identified as the ubiquitous substrates of Protein Kinase C (PKC). There are two identified members of MARCKS family, a 32 kDa ubiquitously expressed protein and a 20 kDa protein that is expressed in brain, macrophages and reproductive tissues. MARCKS proteins have vital role to play in the development of brain, cellular migration and adhesion, phagocytosis, neurosecretion and postnatal survival. MARCKS is also a key regulator in the mucin granule release and thereby secretion of mucus in airway. The phosphorylation domain of MARCKS protein contains the serine residues (serine 152, 156 and 163) that are activated by PKC. Besides PKC, MARCKS is also a target for calcium-calmodulin (CaM) and is reported as the potential protein that mediates a crosstalk between CaM and PKC. MARCKS participates in regulation of cytoskeleton by binding with actin and cell membrane
Anti-phospho-MARCKS (pSer152/156) specifically recognizes MARCKS (80 kDa) phosphorylated at serine 152/156.

免疫原

synthetic phosphorylated peptide derived from the region of rat MARCKS, which is phosphorylated on serine 152/156.

应用

A working dilution of 1:1000 is recommended for detection of MARCKS, phosphorylated at Ser152/156, by immunoblotting in rat hippocampal tissue homogenates.

外形

Solution in 10 mM HEPES, pH 7.5, containing 150 mM NaCl, 100 μg/ml BSA and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD03792006
NACRESNA.44

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous glycerol solution
分子量antigen 80 kDa
species reactivitymouse, rat, human
technique(s)western blot: 1:1000
UniProt登记号P29966
运输dry ice
储存温度−20℃
Gene Informationhuman ... MARCKS(4082)
mouse ... Marcks(17118)
rat ... Marcks(25603)

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