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Monoclonal Anti-p53-Biotin antibody produced in mouse

Monoclonal Anti-p53-Biotin 小鼠抗

品牌
Sigma-Aldrich
货号
P9249
规格纯度
~1 mg/mL, clone DO-1, ascites fluid, buffered aqueous solution
参考价格
9288.44 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

p53 is a tumor suppressor gene expressed in a wide variety of tissues. It is a tetrameric nuclear DNA-binding phosphoprotein. The gene encoding it is localized on human chromosome 17p13.1 and mouse chromosome 11.

免疫原

recombinant human wild type p53. The epitope resides beween amino acids 20-25 of human p53.

应用

Monoclonal Anti-p53-Biotin antibody produced in mouse has been used for Western Blotting.

生化/生理作用

Tumor suppressor p53 has the capability to induce cell cycle arrest and has a role in DNA repair, senescence and apoptosis. It binds to Simian vacuolating virus 40 (SV40) T-antigen and human papilloma virus E6 protein. The p53 gene is mutated in various cancers, such as of the breast, ovarian, bladder, colon and lung.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

储存及稳定性

For continuous use, store at 2-8℃ for up to one month.
For extended storage, freeze in working aliquots.
Repeated freezing and thawing, or storage in “frostfree”freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

其他说明

In order to obtain the best results using various techniques and preparations, we recommend determining optimal working dilutions by titration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD01864735
NACRESNA.41

产品性质

质量水平200
生物来源mouse
偶联物biotin conjugate
抗体形式ascites fluid
antibody product typeprimary antibodies
克隆DO-1, monoclonal
形式buffered aqueous solution
分子量antigen ~53 kDa
species reactivityhuman
浓度~1 mg/mL
technique(s)flow cytometry: suitable
immunocytochemistry: 5-10 μg/mL using human A431
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: 0.5-1 μg/mL using human A431 cell extracts
同位素/亚型IgG2a
UniProt登记号P04637
运输dry ice
储存温度−20℃
Gene Informationhuman ... TP53(7157)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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