产品介绍：
产品说明
应用
PQ401 has been used as:
- an insulin growth factor-1 receptor (IGF-IR) inhibitor in H1299 cells to test its effect on migration suppression
- a reference inhibitor in dose-response measurements studies
- an IGF1R inhibitor in sirtuin 6 (SIRT6)-deficient cardiomyocytes to test its effect on hypertrophy inhibition
包装
10 mg in glass bottle
生化/生理作用
PQ401, a diaryl urea compound that serves as an anti-glioma agent.
PQ401 is an insulin growth factor-1 receptor (IGF-1R) inhibitor.
特点和优势
This compound is featured on the InsR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
基本信息
| 经验(实验)分子式 | C18H16ClN3O2 |
| 分子量 | 341.79 |
| MDL编号 | MFCD00160558 |
| PubChem化学物质编号 | 24724567 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | white |
| 溶解性 | DMSO: >10 mg/mL H2O: <2 mg/mL |
| 储存温度 | 2-8℃ |
| SMILES string | COc1ccc(Cl)cc1NC(=O)Nc2cc(C)nc3ccccc23 |
| InChI | 1S/C18H16ClN3O2/c1-11-9-15(13-5-3-4-6-14(13)20-11)21-18(23)22-16-10-12(19)7-8-17(16)24-2/h3-10H,1-2H3,(H2,20,21,22,23) |
| InChI key | YBLWOZUPHDKFOT-UHFFFAOYSA-N |
安全信息
| 储存分类代码 | 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
