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Osteopontin from bovine milk

品牌
Sigma-Aldrich
货号
O3514
规格纯度
lyophilized powder
参考价格
7749.54 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Osteopontin (OPN) is a multifunctional protein. It is released by macrophages, T cells and epithelial cells. It has 261 amino acid residues with a molecular mass of 29,283 Da. Osteopontin is also called as uropontin. Osteopontin from bovine milk is highly glycosylated and phosphorylated. SPP1 gene (secreted phosphoprotein 1) codes for osteopontin. This gene is located on human chromosome 4 and cow chromosome 6. It has seven exons and six introns.

生化/生理作用

Osteopontin stimulates cell mediated responses, chemotaxis of inflammatory cells and anti-inflammatory responses. It binds to av-containing integrins and stimulate cell adhesion and migration. Osteopontin promotes Th1 type immunity.
A secreted, highly acidic, calcium binding, phosphorylated glycoprotein that is chemotactic for macrophages, smooth muscle cells, endothelial cells, and glial cells. In activated macrophages, OPN inhibits nitric oxide production and cytotoxicity. Human, mouse, rat, pig, and bovine OPN share 40% amino acid sequence identity.

外形

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 2.5 mg bovine serum albumin.

分析说明

The biological activity is measured by its ability to mediate 293 cell adhesion.

基本信息

MDL编号MFCD03100698
NACRESNA.32

产品性质

质量水平100
生物来源bovine milk
无菌性sterile
形式lyophilized powder
分子量 ~60 kDa
包装pkg of 50 μg
technique(s)cell culture | mammalian: suitable
UniProt登记号 P31098
P31096
运输ambient
储存温度−20℃
Gene Informationcow ... SPP1(281499)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)

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