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Oncostatin M from mouse

品牌
Sigma-Aldrich
CAS
106956-32-5
货号
O1637
规格纯度
BioReagent, ≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
参考价格
7836.83 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

Oncostatin M from mouse has been used in the preparation of culture medium for primary culture of mouse fetal hepatoblasts (MFHs).

生化/生理作用

Oncostatin M, LIF, G-CSF, IL-6, and ciliary neurotrophic factor (CNTF) are structurally related members of the same cytokine family sharing similarities in their primary amino acid sequences, predicted secondary structure, and receptor components. Oncostatin M is a growth-regulating cytokine, affecting a number of tumor and normal cells. This material was first identified by its ability to inhibit the growth of A375 melanoma cells and other human tumor cells, but not inhibit the growth of normal human fibroblasts. It acts synergistically with TGF β1 to inhibit the proliferation of tumor cells like A375 melanoma cells. It induces an increase in LDL receptor expression and LDL uptake by hepatoma cells. OSM activates synovial fibroblast-like cells to produce urokinase type plasminogen activator. Oncostatin M is secreted by macrophages and activated T lymphocytes.

外形

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 1.25 mg bovine serum albumin.

分析说明

The biological activity of recombinant mouse OSM was measured by its ability to stimulate 3H-thymidine incorporation in quiescent NIH/3T3 cells.

基本信息

MDL编号MFCD01094784
NACRESNA.32

产品性质

质量水平200
生物来源mouse
重组expressed in E. coli
产品线BioReagent
测定≥97% (SDS-PAGE)
形式lyophilized powder
效能0.25-1 ng/mL EC50
分子量 21 kDa
包装pkg of 25 μg
technique(s)cell culture | mammalian: suitable
杂质 endotoxin, tested
UniProt登记号P53347
储存温度−20℃
Gene Informationmouse ... Osm(18413)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)

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