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Osteoprotegerin/Fc Chimera from mouse

品牌
Sigma-Aldrich
货号
O8137
规格纯度
>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
参考价格
6323.03 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Osteoprotegerin (OPG) is a member of the TNFR (tumor necrosis factor receptor) superfamily that can act as a decoy receptor for RANKL (receptor activator of nuclear factor κ-B ligand) and TRAIL (tumor necrosis factor-related apoptosis-inducing ligand). The primary structure of OPG protein consists of seven distinct domains, four of which corresponds to the extracellular cysteine-rich domains of TNFR proteins and constitutes the soluble OPG. OPG is expressed in a wide variety of tissues including adult heart, lung, kidney and liver. It is secreted both as a monomeric and a dimeric protein.

生化/生理作用

OPG is a soluble secreted member of the tumor necrosis factor receptor superfamily that lacks any apparent cell-association motifs. It regulates the formation of osteoclasts and is involved in the regulation of bone resorption and remodeling. Human and mouse OPG share approximately 84% and 94% amino acid sequence identity, respectively, with rat OPG.
Binding of soluble osteoprotegerin (OPG) to sRANKL (soluble receptor activator of nuclear factor κ-B ligand) inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Changes in the level of serum OPG are associated with atherosclerosis and cardiovascular disorders. It might also be associated with malignancy and plays a regulatory role in multiple myeloma, prostate, breast, bladder and gastric carcinoma. OPG plays a vital role in bone metabolism and is involved in inhibition of ovariectomy-associated bone loss in rats.

外形

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

分析说明

The biological activity is measured by its ability to neutralize apoptosis of mouse L-929 cells treated with 50 ng/ml recombinant human TRAIL.

基本信息

MDL编号MFCD01867131
PubChem化学物质编号24898055
NACRESNA.32

产品性质

质量水平200
生物来源mouse
重组expressed in NSO cells
测定>95% (SDS-PAGE)
形式lyophilized powder
效能25-50 ng/mL ED50
分子量 100 kDa by SDS-PAGE (reducing)
calculated mol wt 70.9 kDa
包装pkg of 100 μg
杂质 endotoxin, tested
UniProt登记号O08712
储存温度−20℃
SMILES stringCCCCCCCCCCC#CCCCCCC(O)=O
InChI1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-10,13-17H2,1H3,(H,19,20)
InChI keyXXUPLYBCNPLTIW-UHFFFAOYSA-N
Gene Informationmouse ... Tnfrsf11b(18383)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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