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18:1-2:0 DG

品牌
Avanti
CAS
86390-77-4
货号
800100O
规格纯度
1-oleoyl-2-acetyl-sn-glycerol, neat oil
参考价格
1124.64 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

18:1-2:0 DG, also called 1-oleoyl-2-acetyl-sn-glycerol (OADG), is a membrane permeable and synthetic analog of diacyl glycerol (DAG).

应用

18:1-2:0 DG (1-oleoyl-2-acetyl-sn-glycerol) may be used:

  • in the induction of superoxide generation in neutrophils
  • as a substrate for platelet-activating factor acetyl hydrolases
  • as a protein kinase C (PKC) activator in adrenal glands

生化/生理作用

18:1-2:0 DG (OAG) halts the inhibition of glucose uptake by the phospholipase C (PLC) inhibitor, U73122. It also inhibits mitochondrial permeability transition pore (MPTP) formation and prevents fatty acid release and necrosis in lung fibroblasts. OAG is a protein kinase C (PKC) activator. It also inhibits TWIK-related acid-sensitive (TASK)-like potassium channels in peripheral arterial chemoreceptors. OAG stimulates 5-lipooxygenase (5-LO) in human polymorphonuclear leukocytes (PMNL).

包装

5 mL PTFE Vial with Screw Cap (800100O-25mg)
5 mL PTFE Vial with Screw Cap (800100O-10mg)

储存及稳定性

Diacylglycerols are conveniently stored in chloroform solutions in glass vials with PTFE-lined caps at -20℃. Under these conditions acyl migration is minimal. Avoid plastic when handling chloroform solutions.

其他说明

Effective concentration: Most biological responses saturate at 20 to 250 μM sn-1,2-dioctanoylglycerol. Only sn-1,2 isomers appear to be active.
Precaution: Since short chain Diacylglycerols mimic effects of the tumor-promoting phorbol diesters in a number of biological systems, extra care should be employed in their handling. Treatment of solutions, vessels and other articles with 1N NaOH before washing or discarding will destroy diacylglycerols.
Delivery to cells: Dry samples of diacylglycerol in chloroform, using a stream of nitrogen. Dissolve the residue in an appropriate volume of ethanol or DMSO, then dilute to the desired aqueous medium.

基本信息

经验(实验)分子式C23H42O5
分子量398.58

产品性质

测定>99% (TLC)
包装pkg of 1 × 10 mg (with screw cap (800100O-10mg))
pkg of 1 × 25 mg (with screw cap (800100O-25mg))
manufacturer/tradenameAvanti Polar Lipids 800100O
运输dry ice
储存温度−20℃
InChI1S/C23H42O5/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)27-20-22(19-24)28-21(2)25/h10-11,22,24H,3-9,12-20H2,1-2H3/b11-10-/t22-/m0/s1
InChI keyPWTCCMJTPHCGMS-YRBAHSOBSA-N

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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